CBDVa
C20H26O4 acid form non-psychoactive
CBDVa is the raw acid form of CBDV. Heat removes one CO2 and turns CBDVa into CBDV, so a gram of CBDVa can yield at most 0.867 g of CBDV.
Turn CBDVa into CBDV with heat
Raw flower holds CBDVa, the acid form. Drag the heat up: past 220 °F the COOH group leaves as CO2 and what stays behind is CBDV.
70 °F: raw, the acid still carries its COOH group
0.4% CBDVa × 0.867 = 0.35% CBDV, plus 0.02% CBDV already there, equals 0.37% Total CBDV.
Worked example. 0.4% CBDVa × 0.867 = 0.35% CBDV, plus 0.02% CBDV already there, equals 0.37% Total CBDV. Example numbers, for illustration only. The 0.867 is the molar-mass ratio of CBDV to CBDVa: the CO2 that leaves weighs about 13.3% of the acid.
What is CBDVa?
CBDVA (cannabidivarinic acid) is the raw acidic form of CBDV, and it relates to CBDA the way THCVA relates to THCA: the same basic shape, with a three-carbon side chain in place of the usual five. It belongs to the varins, a small family of cannabinoids thought to be built from a shorter starting block than the ones that dominate most flower.
The plant stores it as an acid, like its other cannabinoids, and heat or time converts it to CBDV. In most cultivars it is a minor compound, though varins as a group can make up a significant share of the cannabinoids in some ecotypes of Asian and African origin.
Commonly associated effects
CBDVa is commonly associated with the following qualities. These reflect general research and community reports, not guaranteed or medical outcomes.
A shorter tail, probably the same enzymes
CBDVA is understood to come from CBGVA, the varin counterpart of CBGA. CBGVA itself is predicted to be assembled from divarinic acid, a building block made from butanoic acid rather than the hexanoic acid behind the common cannabinoids. The ring-closing step is then thought to mirror the familiar one: researchers believe the CBDA synthase that turns CBGA into CBDA acts on CBGVA as well, with THCA synthase competing for the same substrate. That would explain how a single plant can make CBDVA and THCVA side by side, just as it makes CBDA and THCA.
A small compound with a big exception
In ordinary flower CBDVA is a minor line on the panel. A 2024 study that sampled resin directly from the glandular trichomes of a CBD-rich hemp variety found CBDVA at 0.6 percent of the total cannabinoids, beside 86.4 percent CBDA, and did not detect it in the air-dried flower extract. Some plants break the pattern. In a 2018 survey of a diverse germplasm collection, one plant carried CBDVA as 81.2 percent of its total cannabinoids, making the varin its dominant cannabinoid rather than a footnote.
From CBDVA to CBDV
Like every acid on a certificate, CBDVA converts to its neutral form without any help from an enzyme. Its carboxylic acid group leaves as carbon dioxide, a reaction that runs faster as the temperature climbs and that can also creep along during months of storage at room temperature. CBDVA and THCVA share one formula, C20H26O4, and both shed the same carbon dioxide, so the two varin acids share the same theoretical mass ratio on the way to CBDV and THCV, even though their rings are arranged differently.
Frequently asked questions
Is CBDVA psychoactive?
How is CBDVA different from CBDA?
Are CBDVA and THCVA the same thing?
Why might a lab report not list CBDVA?
Other cannabinoids
Where CBDVa sits in the Heat Row: acids on top, the forms heat makes below, then the rest.
Sources
- PubChem: Cannabidivarinic acid (CID 59444387)
- PubChem: Cannabidiolic acid (CID 160570)
- Welling et al. (2018), Frontiers in Plant Science: Developmental Plasticity of the Major Alkyl Cannabinoid Chemotypes in a Diverse Cannabis Genetic Resource Collection (PMC)
- Kim et al. (2024), Scientific Reports: Comparison of decarboxylation rates of acidic cannabinoids between secretory cavity contents and air-dried inflorescence extracts in Cannabis sativa cv. 'Cherry Wine' (PubMed)
- MacWilliams et al. (2025), Journal of Cannabis Research: Assessing the adaptive role of cannabidivarinic acid (CBDVA) in aphid defense in Cannabis sativa (PubMed)
- Wang et al. (2016), Cannabis and Cannabinoid Research: Decarboxylation Study of Acidic Cannabinoids (PubMed)
Educational information only, not medical advice. Terpene and cannabinoid effects are an active area of research and vary by person, product, and dose. Cannabis is for adults 21+ where legal.
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